January 31, 2024. Male hormones protect against myelin loss by modulating astrocytic chemokines

Multiple sclerosis affects three women for every man. Male hormones including testosterone promote the synthesis of myelin and limit the signs of the disease. Faced with this observation, the research group led by Abdel Ghoumari showed that testosterone and the chemokine receptor CXCR4 involving astrocytes is necessary for myelin regeneration. These results highlight, for the first time, a mechanism of action of pro-myelinating androgens, via chemokine signaling for the combined therapy of myelin pathologies.

Asbelaoui et al, Acta Neuropathol Comm, 2024, 12-Art number 18 /  /  / See press release

27 Mars 2023. Towards a better understanding of the role of male hormones in women with multiple sclerosis

Multiple sclerosis, an autoimmune disease for which there is as yet no cure, affects three women for every one man. Faced with this observation, the research group led by Elisabeth Traiffort within unit U1195 is interested in the role of sex hormones to better understand the differences between men and women in the face of the disease as well as its progression. He has just shown that even if the male hormones – androgens – are present at very low levels in women, their presence is necessary to regenerate the myelin sheath which is destroyed in multiple sclerosis. These results are published in the journal Nature Communications.

Zahaf et al, Nature Communications, 2023, 14-Art number 1592 /  /  / See press comunicate

20 Mars 2023. Thesis defense – Neïké Fernandez

Role of endogenous steroids in cerebroprotection at the acute phase after transient cerebral ischemia.

Direction. Rachida Guenoun

9 Mars 2023. Soutenance de Thèse – Marie-José Boueid

La voie de l’AMPc dans le comportement de cellules de Schwann et la myélinisation périphérique

Direction. Cindy Degerny, Marcel Tawk

8 Mars 2023. Remise de la grand-croix de la légion d’honneur au Professeur Étienne-Émile Baulieu.

Il s’agit de la plus haute distinction dans l’ordre de la légion d’honneur. Elle est détetenue par seulement 67 autres personnes.

9 Mars 2021. March 9 2021. Charcot-Marie Tooth disease: a 100% French therapeutic innovation based on RNA

Charcot-Marie Tooth disease is a disease that causes progressive paralysis of the legs and hands. No treatment is currently available. After more than ten years of research, Lilianne Massade’s team has developed a therapy, based on RNA, allowing mouse models of this disease to regain all their mobility. (Know more)