A word from the director
Dr. Michael Schumacher, DR1 INSERM
Our laboratory « Diseases and Hormones of the Nervous System » addresses unmet medical needs related to diseases and lesions of the central and peripheral nervous systems: protecting neural cells, promoting regeneration, including the regeneration of myelin, and improving functional recovery.
Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination
Squalenoyl siRNA PMP22 nanoparticles to treat mouse models of Charcot-Marie-Tooth disease type 1 A
Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway
Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
News / Highlights
January 31, 2024. Male hormones protect against myelin loss by modulating astrocytic chemokines
Multiple sclerosis affects three women for every man. Male hormones including testosterone promote the synthesis of myelin and limit the signs of the disease. Faced with this observation, the research group led by Abdel Ghoumari showed that testosterone and the chemokine receptor CXCR4 involving astrocytes is necessary for myelin regeneration. These results highlight, for the first time, a mechanism of action of pro-myelinating androgens, via chemokine signaling for the combined therapy of myelin pathologies.
February 7th – 11h00 Brahim Nait-Oumesmar (ICM)
Oligodendrocyte Development and Regeneration : Towards Remyelination Therapeutics in Multiple Sclerosis