A word from the director

Dr. Michael Schumacher, DR1 INSERM

Our laboratory « Diseases and Hormones of the Nervous System » addresses unmet medical needs related to diseases and lesions of the central and peripheral nervous systems: protecting neural cells, promoting regeneration, including the regeneration of myelin, and improving functional recovery.

Teams

Team 1
Nervous system and steroids

Directeur : Michael Schumacher

Team 2
Targeted therapies for neuropathies

Directrice : Liliane Massade

Transversal research programs 

University Paris Saclay

Scientific network

Selected publications

Nature Communications

Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination

 

2023

Communication Biology

Squalenoyl siRNA PMP22 nanoparticles to treat mouse models of Charcot-Marie-Tooth disease type 1 A

2021

Development

 

Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway

 

2022

Autophagy

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

2022

News / Highlights

January 31, 2024. Male hormones protect against myelin loss by modulating astrocytic chemokines

Multiple sclerosis affects three women for every man. Male hormones including testosterone promote the synthesis of myelin and limit the signs of the disease. Faced with this observation, the research group led by Abdel Ghoumari showed that testosterone and the chemokine receptor CXCR4 involving astrocytes is necessary for myelin regeneration. These results highlight, for the first time, a mechanism of action of pro-myelinating androgens, via chemokine signaling for the combined therapy of myelin pathologies.

Asbelaoui et al, Acta Neuropathol Comm, 2024, 12-Art number 18 /  /  / See press release

Seminars

29 Mai, 11h00 Benoît Schneider (Ecole Polytechnique)
Protéine prion cellulaire, signalisation et maladies neurodégénératives amyloïdes : vers l’identification de cibles thérapeutiques

To reach us

U1195 Inserm
Bâtiment Gregory Pincus
80 rue du Général Leclerc
94276 Le Kremlin Bicêtre

Position on Google Map

+33 1 49 59 19 98

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