A word from the director

Dr. Michael Schumacher, DR1 INSERM

Our laboratory « Diseases and Hormones of the Nervous System » addresses unmet medical needs related to diseases and lesions of the central and peripheral nervous systems: protecting neural cells, promoting regeneration, including the regeneration of myelin, and improving functional recovery.


Team 1
Nervous system and steroids

Directeur : Michael Schumacher

Team 2
Targeted therapies for neuropathies

Directrice : Liliane Massade

Transversal research programs 

University Paris Saclay

Scientific network

Selected publications

Nature Communications

Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination



Communication Biology

Squalenoyl siRNA PMP22 nanoparticles to treat mouse models of Charcot-Marie-Tooth disease type 1 A




Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway




Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies


News / Highlights

March 27, 2023. Role of male hormones in women with multiple sclerosis

Multiple sclerosis affects three women for every one man. There is as yet no cure. The research group led by Elisabeth Traiffort has just shown that even if the male hormones – androgens – are present at very low levels in women, their presence is necessary to regenerate the myelin sheath which is destroyed in multiple sclerosis. These results are published in the journal Nature Communications.

Zahaf et al, Nature Communications, 2023, 14-Art number 1592                  Listen on « France-Culture » radio


10 Oct 2023, 12h00 – Carmen Villmann (Institute for Clincal Neurobiology, Universitätsklinikum Würzburg, Würzburg, Allemagne)

 » New Molecular Insights into an Old Neurological Disorder – Startle Disease and Beyond « 

10 Oct 2023, 12h40 – Natascha Schaefer (Institute for Clincal Neurobiology, Universitätsklinikum Würzburg, Würzburg, Allemagne)

 » Necessity of 3D neuronal tissue models to further understand the complexity of rare diseases « 

22 May 2023, 14h30 – Gonzalo Yévenes (Universidad de Concepción, Concepción, Chili)

« Glycinergic neurotransmission: a growing field« .

To reach us

U1195 Inserm
Bâtiment Gregory Pincus
80 rue du Général Leclerc
94276 Le Kremlin Bicêtre

Position on Google Map

+33 1 49 59 19 98