A word from the director

Dr. Michael Schumacher, DR1 INSERM

Our laboratory « Diseases and Hormones of the Nervous System » addresses unmet medical needs related to diseases and lesions of the central and peripheral nervous systems: protecting neural cells, promoting regeneration, including the regeneration of myelin, and improving functional recovery.

Teams

Team 1
Nervous system and steroids

Directeur : Michael Schumacher

Team 2
Targeted therapies for neuropathies

Directrice : Liliane Massade

Transversal research programs 

University Paris Saclay

Scientific network

Selected publications

Nature Communications

Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination

 

2023

Communication Biology

Squalenoyl siRNA PMP22 nanoparticles to treat mouse models of Charcot-Marie-Tooth disease type 1 A

2021

Development

 

Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway

 

2022

Autophagy

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

2022

Collaborations

Plateaux Scientifiques

News / Highlights

March 27, 2023. Towards a better understanding of the role of male hormones in women with multiple sclerosis

Multiple sclerosis, an autoimmune disease for which there is as yet no cure, affects three women for every one man. Faced with this observation, the research group led by Elisabeth Traiffort within unit U1195 is interested in the role of sex hormones to better understand the differences between men and women in the face of the disease as well as its progression. He has just shown that even if the male hormones – androgens – are present at very low levels in women, their presence is necessary to regenerate the myelin sheath which is destroyed in multiple sclerosis. These results are published in the journal Nature Communications.

Zahaf et al, Nature Communications, 2023, 14-Art number 1592

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Nous joindre

U1195 Inserm
Bâtiment Gregory Pincus
80 rue du Général Leclerc
94276 Le Kremlin Bicêtre

+33 1 49 59 19 98

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