A word from the director
Dr. Michael Schumacher, DR1 INSERM
Our laboratory « Diseases and Hormones of the Nervous System » addresses unmet medical needs related to diseases and lesions of the central and peripheral nervous systems: protecting neural cells, promoting regeneration, including the regeneration of myelin, and improving functional recovery.
Teams
Team 1
Nervous system and steroids
Directeur : Michael Schumacher
Team 2
Targeted therapies for neuropathies
Directrice : Liliane Massade
Transversal research programs
University Paris Saclay
Scientific network
Selected publications
Nature Communications
Androgens show sex-dependent differences in myelination in immune and non-immune murine models of CNS demyelination
2023
Communication Biology
Squalenoyl siRNA PMP22 nanoparticles to treat mouse models of Charcot-Marie-Tooth disease type 1 A
2021
Development
Timely Schwann cell division drives peripheral myelination in vivo via the laminin/cAMP pathway
2022
Autophagy
Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
2022
Collaborations
Plateaux Scientifiques
News / Highlights
March 27, 2023. Towards a better understanding of the role of male hormones in women with multiple sclerosis
Multiple sclerosis, an autoimmune disease for which there is as yet no cure, affects three women for every one man. Faced with this observation, the research group led by Elisabeth Traiffort within unit U1195 is interested in the role of sex hormones to better understand the differences between men and women in the face of the disease as well as its progression. He has just shown that even if the male hormones – androgens – are present at very low levels in women, their presence is necessary to regenerate the myelin sheath which is destroyed in multiple sclerosis. These results are published in the journal Nature Communications.
Zahaf et al, Nature Communications, 2023, 14-Art number 1592
Nous joindre
U1195 Inserm
Bâtiment Gregory Pincus
80 rue du Général Leclerc
94276 Le Kremlin Bicêtre
+33 1 49 59 19 98
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